If you have had a course of modified-RNA COVID injections and your antibody titer against the spike protein is still meaningfully elevated five years later, the right reaction is not relief that your immune system is “working.” It is curiosity about why the signal hasn’t faded — and a willingness to do something about it.
The original pharmacokinetic models supplied by the vaccine manufacturers said the lipid nanoparticles and synthetic mRNA would degrade within days. The resulting spike protein, we were told, would clear shortly after that. Independent peer-reviewed research over the last several years has told a different story. Spike protein has been detected in human circulation up to 187 days after vaccination. It has been found, unbound and full-length, in the plasma of young patients hospitalized with post-vaccine myocarditis. And the proposed mechanisms for why this happens — residual plasmid DNA contamination acting as a long-running template, and intracellular reverse transcription via LINE-1 — are biologically plausible enough that the conservative clinical posture is to assume ongoing spike production is real in symptomatic patients, and to intervene accordingly.
The CI Mavericks Health Advisory position
The evidence for spike persistence is now sufficient to warrant active mitigation in anyone with documented elevated post-vaccine antibody titers or with symptoms consistent with post-vaccine syndrome. The framework is three-pronged: neutralize circulating spike, reduce its capacity to drive inflammation, and actively support excretion through pathways the liver and kidneys do not adequately address on their own. All three are accomplishable in 2026 with widely available interventions.
What “Spikeopathy” Actually Means
Spikeopathy is the term given by Parry et al. (2023) to the pathogenic properties of the SARS-CoV-2 spike protein itself — whether produced by viral infection or generated inside human cells following mRNA vaccination. The spike protein is not an inert decoy. It binds the ACE2 receptor, which is expressed on virtually every tissue type in the body. It is associated with endothelial dysfunction, inflammatory cascades, and tissue tropism in distant organs. And, by lipid-nanoparticle biodistribution, it is produced not only at the injection site but in tissues throughout the body.
The downstream clinical signal is consistent with this: cardiovascular inflammation, autoimmune-pattern presentations, gut microbiome disruption (Rubio-Casillas et al., 2024), and a growing post-vaccine-syndrome literature that no longer has the luxury of being dismissed.
The Three-Step Intervention Framework
The framework that follows is drawn primarily from the published work of Dr. Peter McCullough — a cardiologist, internist, epidemiologist, and one of the most-published researchers in the world on the modified-RNA injections and their sequelae. None of it is novel CI Mavericks invention; what is novel is publishing it in one place, in plain language, for an investor audience that has not been given an honest place to discuss it.
Step 1 — Targeted Supplementation
Dr. McCullough’s recommended multi-compound formulation combines nattokinase (a fibrinolytic enzyme demonstrated to dissolve spike protein in preclinical models), dandelion root, bromelain (a proteolytic enzyme with documented spike-binding activity), turmeric root extract, selenium, black seed, and black pepper fruit. A pre-formulated version runs about $81 per month:
Augmented NAC is a sensible second-line addition — about $60 per month in quantities of three:
Mechanistic background on the augmented-NAC approach is at augmentednac.com/en/science and zerospike.org.
Step 2 — Daily Sauna
Seven sessions per week. Minimum 30 minutes each. Traditional heat sauna at 80–100 °C (176–212 °F), or far-infrared at 60–66 °C (140–150 °F). The mechanism in both cases is the same: sweat volume. More is better.
Two mechanisms are well-documented: sauna use produces immediate increases in white blood cells, lymphocytes, and neutrophils (immune stimulation), and induces Heat Shock Proteins that help cells repair misfolded proteins and reduce systemic inflammation (cytoprotection). A third, more speculative mechanism — direct spike excretion via sweat — is supported by biopsy evidence that spike protein deposits in sweat glands, and is an area of active research.
Step 3 — Monitor With Realistic Timing
The natural half-life of circulating IgG is long enough that repeating antibody tests at six-month intervals will almost certainly show no change, even when the underlying spike burden has dropped substantially. Nine months minimum, twelve months ideal. Better still is direct measurement of circulating spike protein, which has just become available in the U.S. — though for now it remains a research-protocol assay accessible primarily through Dr. McCullough’s group. We expect this to migrate to mainstream laboratories within six to twelve months.
Why CI Mavericks Is Covering This
Because we are a wealth-and-health advisory firm and the two are inseparable. A compounding portfolio is worth nothing if you are not around to enjoy it. Our members — founders, physicians, investors, operators — need their bodies to last as long as their businesses. And the question of what to do with five years of elevated spike antibody is one that almost no traditional advisory or medical setting is willing to engage honestly. We will.
This is not medical advice. Action on any of the above should be taken in consultation with a licensed physician who knows your full clinical picture and current medication list. What we can offer is what we always offer: an honest read of where the evidence currently sits, and a practical framework for what to do with it.
Read the full research report
This post is a summary. The full CI Mavericks Health Advisory research report — “Spikeopathy: Persistence, Pathology, and What To Do About It” — covers the peer-reviewed evidence base in depth, the two principal mechanisms proposed for ongoing spike production (plasmid DNA contamination and LINE-1 reverse transcription), and the full intervention framework with safety considerations. Available on the Reports page at cimavericks.com.
Disclaimer. This article is for informational and educational purposes only. It does not constitute medical advice, and does not establish a physician-patient relationship between CI Mavericks Advisory Services or any of its contributors and any reader. The supplements, sauna protocols, and laboratory testing approaches discussed are summarized from third-party clinicians and researchers, primarily Dr. Peter McCullough, and are not endorsed as treatment by CI Mavericks. Readers must consult their own licensed physician before beginning any of the interventions discussed. CI Mavericks Advisory Services has no financial relationship with any supplement company or laboratory referenced.